Cumulative lead exposure is associated with reduced olfactory recognition performance in elderly men: the Normative Aging Study
Identifieur interne : 000781 ( Main/Exploration ); précédent : 000780; suivant : 000782Cumulative lead exposure is associated with reduced olfactory recognition performance in elderly men: the Normative Aging Study
Auteurs : Rachel Grashow [États-Unis] ; David Sparrow [États-Unis] ; Howard Hu [Canada] ; Marc G. Weisskopf [États-Unis]Source :
- Neurotoxicology [ 0161-813X ] ; 2015.
Abstract
Olfactory dysfunction has been identified as an early warning sign for Alzheimer’s disease, Parkinson’s disease, dementia and more. A few occupational and environmental exposures have also been associated with reduced olfactory function, although the effects of long term environmental exposure to lead on olfactory dysfunction have not been explored. Here we performed olfactory recognition testing in elderly men in a community-dwelling cohort and examined the association with cumulative lead exposure, as assessed by lead in tibial and patellar bone.
Olfactory recognition was measured in 165 men from the Normative Aging Study (NAS) who had previously taken part in bone lead measurements using K-X-Ray fluorescence (KXRF). Olfactory recognition was measured using the University of Pennsylvania Smell Identification Test (UPSIT). Associations between olfactory recognition, global cognition and cumulative lead exposure were estimated using linear regression, with additional adjustment for age, smoking, and functional polymorphism status for hemochromatosis (
The average age of the NAS participants at the time of olfactory recognition testing was 80.3 (standard deviation or SD = 5.7) years. Mean tibia lead was 16.3 (SD = 12.0) μg/g bone, mean patella lead was 22.4 (SD = 14.4) μg/g bone, and mean UPSIT score was 26.9 out of 40 (SD = 7.0). Consistent with previous findings, age at olfaction testing was negatively associated with UPSIT score. Tibia (but not patella) bone lead was negatively associated with olfaction recognition (per 15 μg/g tibia lead: β = −1.57; 95% CI: −2.93, −0.22; p = 0.02) in models adjusted for smoking and age. Additional adjustment for education did not significantly change results. Of all the genes explored, only the presence of one or more HFE variant alleles was significantly associated with olfaction recognition (HFE β = 2.26; 95% CI: 0.09, 4.43; p = 0.04). In a model containing the HFE term and a lead term, the tibia lead parameter estimate dropped by 21% (per 15 μg/g tibia lead: β = −1.25; 95% CI: −2.64, 0.14; p = 0.08) while the HFE term dropped 15% (β = 1.91; 95% CI: −0.28, 4.10; p=0.09). None of the other gene terms were associated with olfactory recognition in this cohort, nor were any gene-lead interaction terms significant. Additional sensitivity analysis in men with MMSE scores of 25 or higher (n = 149) showed a similar but slightly attenuated association between lead and olfactory recognition (per 15 μg/g tibia lead β = −1.39; 95% CI: −3.00, 0.22; p = 0.09)
Cumulative exposure to lead is associated with reduced olfactory recognition in a cohort of elderly men. The association was similar but not significant in men with better cognitive function as measured by the MMSE. Iron metabolism gene status may also affect olfactory function.
Url:
DOI: 10.1016/j.neuro.2015.06.006
PubMed: 26121922
PubMed Central: 4523435
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000806
- to stream Pmc, to step Curation: 000806
- to stream Pmc, to step Checkpoint: 000333
- to stream Ncbi, to step Merge: 001C26
- to stream Ncbi, to step Curation: 001C26
- to stream Ncbi, to step Checkpoint: 001C26
- to stream Main, to step Merge: 000782
- to stream Main, to step Curation: 000781
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cumulative lead exposure is associated with reduced olfactory recognition performance in elderly men: the Normative Aging Study</title>
<author><name sortKey="Grashow, Rachel" sort="Grashow, Rachel" uniqKey="Grashow R" first="Rachel" last="Grashow">Rachel Grashow</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Department of Civil and Environmental Engineering, Northeastern University, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Civil and Environmental Engineering, Northeastern University, Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sparrow, David" sort="Sparrow, David" uniqKey="Sparrow D" first="David" last="Sparrow">David Sparrow</name>
<affiliation wicri:level="2"><nlm:aff id="A3">VA Boston Healthcare System and Boston University Schools of Public Health and Medicine, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>VA Boston Healthcare System and Boston University Schools of Public Health and Medicine, Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hu, Howard" sort="Hu, Howard" uniqKey="Hu H" first="Howard" last="Hu">Howard Hu</name>
<affiliation wicri:level="4"><nlm:aff id="A5">Dalla Lana School of Public Health. University of Toronto, Toronto, ON, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Dalla Lana School of Public Health. University of Toronto, Toronto, ON</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Weisskopf, Marc G" sort="Weisskopf, Marc G" uniqKey="Weisskopf M" first="Marc G." last="Weisskopf">Marc G. Weisskopf</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26121922</idno>
<idno type="pmc">4523435</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523435</idno>
<idno type="RBID">PMC:4523435</idno>
<idno type="doi">10.1016/j.neuro.2015.06.006</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">000806</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000806</idno>
<idno type="wicri:Area/Pmc/Curation">000806</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000806</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000333</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000333</idno>
<idno type="wicri:Area/Ncbi/Merge">001C26</idno>
<idno type="wicri:Area/Ncbi/Curation">001C26</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001C26</idno>
<idno type="wicri:doubleKey">0161-813X:2015:Grashow R:cumulative:lead:exposure</idno>
<idno type="wicri:Area/Main/Merge">000782</idno>
<idno type="wicri:Area/Main/Curation">000781</idno>
<idno type="wicri:Area/Main/Exploration">000781</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cumulative lead exposure is associated with reduced olfactory recognition performance in elderly men: the Normative Aging Study</title>
<author><name sortKey="Grashow, Rachel" sort="Grashow, Rachel" uniqKey="Grashow R" first="Rachel" last="Grashow">Rachel Grashow</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Department of Civil and Environmental Engineering, Northeastern University, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Civil and Environmental Engineering, Northeastern University, Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sparrow, David" sort="Sparrow, David" uniqKey="Sparrow D" first="David" last="Sparrow">David Sparrow</name>
<affiliation wicri:level="2"><nlm:aff id="A3">VA Boston Healthcare System and Boston University Schools of Public Health and Medicine, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>VA Boston Healthcare System and Boston University Schools of Public Health and Medicine, Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hu, Howard" sort="Hu, Howard" uniqKey="Hu H" first="Howard" last="Hu">Howard Hu</name>
<affiliation wicri:level="4"><nlm:aff id="A5">Dalla Lana School of Public Health. University of Toronto, Toronto, ON, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Dalla Lana School of Public Health. University of Toronto, Toronto, ON</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Weisskopf, Marc G" sort="Weisskopf, Marc G" uniqKey="Weisskopf M" first="Marc G." last="Weisskopf">Marc G. Weisskopf</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA</wicri:regionArea>
<wicri:noRegion>MA</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Neurotoxicology</title>
<idno type="ISSN">0161-813X</idno>
<idno type="eISSN">1872-9711</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Introduction</title>
<p id="P2">Olfactory dysfunction has been identified as an early warning sign for Alzheimer’s disease, Parkinson’s disease, dementia and more. A few occupational and environmental exposures have also been associated with reduced olfactory function, although the effects of long term environmental exposure to lead on olfactory dysfunction have not been explored. Here we performed olfactory recognition testing in elderly men in a community-dwelling cohort and examined the association with cumulative lead exposure, as assessed by lead in tibial and patellar bone.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P3">Olfactory recognition was measured in 165 men from the Normative Aging Study (NAS) who had previously taken part in bone lead measurements using K-X-Ray fluorescence (KXRF). Olfactory recognition was measured using the University of Pennsylvania Smell Identification Test (UPSIT). Associations between olfactory recognition, global cognition and cumulative lead exposure were estimated using linear regression, with additional adjustment for age, smoking, and functional polymorphism status for hemochromatosis (<italic>HFE</italic>
), transferrin (<italic>TfC2</italic>
), glutathione-s-transferase Pi1 (<italic>GSTP1</italic>
) and apolipoprotein E (<italic>APOE</italic>
) genotypes. Sensitivity analyses explored olfactory recognition in men with high global cognitive function as measured using the Mini-Mental Status Exam (MMSE).</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P4">The average age of the NAS participants at the time of olfactory recognition testing was 80.3 (standard deviation or SD = 5.7) years. Mean tibia lead was 16.3 (SD = 12.0) μg/g bone, mean patella lead was 22.4 (SD = 14.4) μg/g bone, and mean UPSIT score was 26.9 out of 40 (SD = 7.0). Consistent with previous findings, age at olfaction testing was negatively associated with UPSIT score. Tibia (but not patella) bone lead was negatively associated with olfaction recognition (per 15 μg/g tibia lead: β = −1.57; 95% CI: −2.93, −0.22; p = 0.02) in models adjusted for smoking and age. Additional adjustment for education did not significantly change results. Of all the genes explored, only the presence of one or more HFE variant alleles was significantly associated with olfaction recognition (HFE β = 2.26; 95% CI: 0.09, 4.43; p = 0.04). In a model containing the HFE term and a lead term, the tibia lead parameter estimate dropped by 21% (per 15 μg/g tibia lead: β = −1.25; 95% CI: −2.64, 0.14; p = 0.08) while the HFE term dropped 15% (β = 1.91; 95% CI: −0.28, 4.10; p=0.09). None of the other gene terms were associated with olfactory recognition in this cohort, nor were any gene-lead interaction terms significant. Additional sensitivity analysis in men with MMSE scores of 25 or higher (n = 149) showed a similar but slightly attenuated association between lead and olfactory recognition (per 15 μg/g tibia lead β = −1.39; 95% CI: −3.00, 0.22; p = 0.09)</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P5">Cumulative exposure to lead is associated with reduced olfactory recognition in a cohort of elderly men. The association was similar but not significant in men with better cognitive function as measured by the MMSE. Iron metabolism gene status may also affect olfactory function.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
<li>États-Unis</li>
</country>
<region><li>Massachusetts</li>
<li>Ontario</li>
</region>
<settlement><li>Toronto</li>
</settlement>
<orgName><li>Université de Toronto</li>
</orgName>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Grashow, Rachel" sort="Grashow, Rachel" uniqKey="Grashow R" first="Rachel" last="Grashow">Rachel Grashow</name>
</noRegion>
<name sortKey="Grashow, Rachel" sort="Grashow, Rachel" uniqKey="Grashow R" first="Rachel" last="Grashow">Rachel Grashow</name>
<name sortKey="Sparrow, David" sort="Sparrow, David" uniqKey="Sparrow D" first="David" last="Sparrow">David Sparrow</name>
<name sortKey="Sparrow, David" sort="Sparrow, David" uniqKey="Sparrow D" first="David" last="Sparrow">David Sparrow</name>
<name sortKey="Weisskopf, Marc G" sort="Weisskopf, Marc G" uniqKey="Weisskopf M" first="Marc G." last="Weisskopf">Marc G. Weisskopf</name>
</country>
<country name="Canada"><region name="Ontario"><name sortKey="Hu, Howard" sort="Hu, Howard" uniqKey="Hu H" first="Howard" last="Hu">Howard Hu</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000781 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000781 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Canada |area= ParkinsonCanadaV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:4523435 |texte= Cumulative lead exposure is associated with reduced olfactory recognition performance in elderly men: the Normative Aging Study }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26121922" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonCanadaV1
This area was generated with Dilib version V0.6.29. |